NSAIDs are a Big Risk for Pregnancy

Women who are considering pregnancy and those already in their first trimester of pregnancy should be warned that taking non-steroidal anti-inflammatory drugs (NSAIDs) may increase their risk for miscarriage. Physicians already deter the use of NSAIDs in the last trimester of pregnancy because it can interfere with the healthy development of fetal circulation.


“I would strongly suggest that women take no non-steroidal anti-inflammatory drugs during the first trimester”   Anick Berard


“If a woman is taking an NSAID for a chronic condition she really has to talk to her health care provider to see if it’s feasible to stop at least during the first trimester.”


“Gestational exposure to any type or dosage of non-aspirin NSAIDs may increase risk of spontaneous abortion. These drugs should be used with caution during pregnancy.”


In 2011, a group of Canadian and French researchers conducted a study for women in their first trimester who were between the ages of 15 and 45.  They analyzed over 55,000 women in which 4,700 suffered a miscarriage and compared those to the control group who did not. The studies unveiled that 7.5% of the women who suffered a miscarriage in the beginning weeks of their pregnancy had filled at least one prescription for an NSAID.  The researchers considered anyone in the study to be using NSAIDs if they had filled at least one prescription just before pregnancy or within the 20 weeks after conception. Specifically named drugs had differing risks associated with them. Diclofenac, which is used to treat pain and inflammatory disorders and is commonly given to arthritis patients, tripled the risk of miscarriage, naproxen (Aleve), increased the risk by 2.64 times, and ibprofen (Advil, Motrin) doubled the risk.


No one is certain how NSAIDs might cause miscarriage but researchers have a theory that the NSAIDs might interfere with levels of the hormones called prostaglandins, which are involved in inducing labor. In pregnancy, prostaglandins decrease in the uterus in a consistent way, but it is quite possible that the NSAIDs cause these levels to fluctuate Anick Berard, director of the research unit on medications and pregnancy at Centre Hospitalier Universitaire Ste. Justine, suggests. For pregnant women who are experiencing pain during pregnancy, Berard, suggests they avoid NSAIDs and turn to acetaminophen which is considered a safe alternative during the early stages of pregnancy.  For women with conditions such as rheumatoid arthritis or lupus she says it is better to plan the pregnancy and discuss alternative treatments with a doctor beforehand.

Author Information: RTPR.com

For more visit Christina Anthony’s Blog at http://rtpr.com/manage/blog/1400

Editor’s Note — PainKillerAwareness.org is committed to sharing information we have gathered through extensive analysis of research studies, credible media sources and statistics. Our goal is to provide readers with the information that we gather along with the corresponding source. This will allow our readers to make intelligent and informed decisions about the painkillers they choose to consume. This particular blog post/article is an ongoing article that will have new information added to it as it is discovered or released. If our readers have important information that is not in this article, we would appreciate it if you would share the information and source with us through our contact page.


5 Responses to NSAIDs are a Big Risk for Pregnancy

  1. Lucas Wyrsch says:

    Thanks Painkickers for sharing! We all need to know how to get rid of some pains and yes, you had a strong influence in changing my mind on many subjects! Have a happy and prosperous Tuesday! Best, Lucas

  2. ron says:

    testing reply

  3. Lori Bhada says:

    This article makes me think of friends that have lost pregnancies and wondering how many may have been linked to something we have been led to believe was safe. Just one more reason I am committed to being a Wellness Coach and helping people be aware of their options.

  4. hello there and thanks for your info ? I have definitely picked up something new from proper here. I did however experience a few technical points the use of this website, as I experienced to reload the website a lot of occasions previous to I could get it to load properly. I were considering in case your web host is OK? No longer that I am complaining, but sluggish loading cases instances will often have an effect on your placement in google and could damage your high-quality ranking if ads and marketing with Adwords. Well I am including this RSS to my e-mail and can glance out for a lot more of your respective fascinating content. Ensure that you update this once more soon..

  5. Guy Siverson says:

    Pregnancy is no time to take risks with drugstore medications. If there is danger possible then it would be highly advisable to do everything within one’s power to avoid such dangers. Thanks for sharing this valuable information in an effort to raise awareness about the dangers of pain killers.

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